Complications of Botulinum Toxin A:
A Comprehensive Review
Volume 1 - Issue 1
Steven H Dayan1,2,3, Christopher Ian Newberry4*, Eric W Cerrati4 and Nazanin Ashourian1,3
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- 1DeNova Research, Chicago, Illinois
- 2Department of Otolaryngology, Division of Facial Plastic and Reconstructive Surgery, University of Illinois Medical Center, Chicago, Illinois
- 3Chicago Center for Facial Plastic Surgery, Chicago, Illinois
- 4Division of Otolaryngology-Head and Neck Surgery, University of Utah, UT, Austin
*Corresponding author:
Christopher Ian Newberry, Division of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake
City, UT, Austin
Received: July 23, 2018; Published: July 30, 2018
DOI: 10.32474/SJO.2018.01.000105
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Abstract
Botulinum toxin was first described in the 1800’s and has since found its permanent place in the medical community becoming
the main ingredient of the most common cosmetic procedure. The injections have also gained multiple FDA approvals for both
cosmetic and therapeutic indications. While the toxin injections have demonstrated a long history of safety, the drug remains highly
controversial among regulators and legal entities. The following review provides a detailed, up-to-date description of botulinum
toxin injection complications. Included topics are history, local and distal effects, long term safety, immunogenicity, use in pregnancy,
and cosmetic use.
Key Points
a. Despite being one of the most studied pharmaceuticals and demonstrating a long history of safety, botulinum neurotoxin
serotype A (BoNTA) remains to be a rather controversial drug and is under rigid scrutiny by the regulators and legal entities.
b. Given that botulinum toxin injections have become the most frequent cosmetic procedure, providers must be familiar with the
product and the data outlining its safety profile.
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